Effect of dimethyl fumarate (DMF) and transforming growth factor (TGFb) on gene expression in dermal fibroblasts

Primary adult dermal fibroblasts isolated from forearm skin biopsy of 3 healthy donors were treated with DMF and TGFb. 3 cell lines of dermal fibroblasts were derived from skin biopses from healthy donors. All cell lines were subjected to 4 treatments: control (DMSO), dimethyl fumarate (DMF), TGFb, and TGFb+DMF. The goal of the study was to identify sets of genes regulated by different treatments.