This model incorporates a filtering mechanism where a specified proportion (e.g., 30%) of the genotype combinations derived from the pathogenic combinations are “lost” or excluded across all populatio
For each gene, Chr/Mb denotes chromosome and genomic position (Megabases), dbSNP is the rs-identifier for the assayed SNP, and Nuc is the nucleotide substitution at a SNP. Frqassoc and Z-scores are wi
Analysis of simulated disease architecture with 180 causal 1Mbp loci yielding a true . In each locus, 1–10 causal variants were sampled from either low-frequency () of common (MAF) WTCCC2 SNPs. For ea
