Supplementary Table S2: Sig3 scores and FGA values in LMS tumor samples. Sig3+ samples are predicted with a classifier trained in WGS LMS data. FGA values are calculated on CNVkit-based copy number pr

Figshare2023-12-15 更新30

3,N(4)-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

DNA损伤修复

致突变加合物

Exocyclic DNA adducts are generated in cellular DNA by various industrial pollutants such as the carcinogen vinyl chloride and by endogenous products of lipid peroxidation. The etheno derivatives of p

PubMed Central1998-07-21 更新00

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

DNA lesions can frequently precede DNA:RNA hybrid accumulation [RNA-seq]

DNA损伤修复

DNA:RNA杂交体

While DNA:RNA hybrids contribute to multiple genomic transactions, their unscheduled formation is a recognized source of DNA lesions. Here, through a suite of systematic screens, we rather observed th

NIAID Data Ecosystem10

Multiple DNA repair pathways collectively protect against DNA damage-induced replicative aging.

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