Understanding how uniquely human genetic changes altered developmental processes is essential to understanding human evolution. We investigated the role of the Human Accelerated Region HACNS1 in human

NIAID Data Ecosystem30

An ancient fecundability-associated polymorphism creates a new GATA2 binding site in a distal enhancer of HLA-F. An ancient fecundability-associated polymorphism creates a new GATA2 binding site in a distal enhancer of HLA-F

生殖遗传学

基因调控机制

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem20

Effects of LMTK2 knockdown on total RNA expression in CFBE41o- cells after TGFβ1 or vehicle control (HCl+BSA) treatment. Effects of LMTK2 knockdown on total RNA expression in CFBE41o- cells after TGFβ1 or vehicle control (HCl+BSA) treatment

基因调控机制

TGF-β信号通路

The purpose of this study was to increase the current knowledge about the LMTK2 network and its intersection with the TGF-β1 signaling pathway. To understand how the LMTK2 and TGF-β1 pathways intercon

NIAID Data Ecosystem30

Transcription factor trapping by RNA in gene regulatory elements (GRO-Seq). Mus musculus

转录因子-RNA互作

基因调控机制

Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA

NIAID Data Ecosystem20

Competition for DNA binding between paralogous transcription factors determines their genomic occupancy and regulatory functions

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