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To dissect the requirements of membrane protein degradation from the ER, we expressed the mouse major histocompatibility complex class I heavy chain H-2K(b) in yeast
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Contribution of the Unfolded Protein Response (UPR) transcription factor XBP1 to brain aging
In this project we aimed to evaluate the contribution of endoplasmic reticulum stress sensor IRE1 and its downstream transcription factor XBP1s to mammalian brain aging. We compared traits associated
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Gene expression profiling of chondrodysplasia mutants and isogenic controls during hypertrophic induction from iPSCs. Gene expression profiling of chondrodysplasia mutants and isogenic controls during hypertrophic induction from iPSCs
In order to better understand chondrodysplasia disease mechanisms, we induced hypertrophic chondrocytes from chondrodysplasia-specific iPSCs and analyzed their gene expression profile. This dataset in
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The trypanosome Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
: In the endoplasmic reticulum (ER), the ER-associated degradation (ERAD) pathway targets incorrectly folded and unassembled proteins into the cytoplasm for turnover by the proteasome. Previously, we
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A dynamic unfolded protein response contributes to the control of cortical neurogenesis. Mus musculus
The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-related progenitors. At the onset of corticogenesis, the first-born progenitors are apical progenitors (APs) w
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Transcript-specific translational regulation in the unfolded protein response of Saccharomyces cerevisiae. Saccharomyces cerevisiae
The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) causes stress and induces the unfolded protein response (UPR) which is characterised in part by the transcriptional
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