Structural covariance of thickness is organized along neurogenetic and neurodevelopmental axes

Structural covariance of regional cortical thickness reflects genetic processes, structural, and functional connectivity, and relates to individual differences in health and disorder ([Alexander-Bloch A et al. 2013](https://www.ncbi.nlm.nih.gov/pubmed/23531697)). Previous studies of the mammalian cortex have specified various natural dimensions of systematic variations in cortical features as a function of laminar differentiation, cytoarchitecture, gene expression, and functional connectivity ([Huntenburg JM et al. 2018](https://www.ncbi.nlm.nih.gov/pubmed/29203085)). These dimensions have behavioral ramifications ([Huntenburg JM et al. 2018](https://www.ncbi.nlm.nih.gov/pubmed/29203085)), and relate to the timing of neurogenesis and neurogenetic origin of cortical organization ([Sanides F 1962; Goulas A et al. 2019](https://www.springer.com/de/book/9783540028864)). Here, we studied the topology of structural covariance using a data-driven framework in humans and macaque monkeys and explore its genetic origin.