Solvent Effect on Pseudopolymorphism of Hemicyclohexylcucurbit[6]uril

Novel covalent macrocycle, hmcyCuc6, has been synthesized and its four pseudopolymorphs were reported. HmcyCuc6 is highly selective to CH2Cl2, CHCl3, and CCl4 in the crystal growth, and the selectivity of the hmcyCuc6 toward these solvent molecules may be related to the symmetry of the solvent molecules. In addition, four pseudopolymorphs can be simply controlled by changing the crystallization solvent system. To our best knowledge, the pseudopolymorphism of the cucurbit[n]uril homologues is reported for the first time.