SUMOylation affects many aspects of target proteins such as activity, stability, localization and protein-protein interactions. We have found that SUMOylation of YTHDF2 increased its binding activity

NIAID Data Ecosystem60

METTL14 / YTHDF1 mediates m6A modification of PTBP1 to regulate PDGF-BB-induced airway smooth muscle cell function

哮喘分子机制

m6A甲基化调控

Increased proliferation and migration of abnormal airway smooth muscle cells (ASMCs) are significantly associated with asthma. This study aimed to investigate the effects of methyltransferase-like 14

NIAID Data Ecosystem40

Mettl3/m6A promotes translation of pathogenic mRNAs to mediate cystogenesis in mouse models of ADPKD

m6A甲基化调控

多囊肾病囊肿形成

Purpose: Determine the differential m6A methylation pattern of Mettl3 between wildtype, Pkd1F/RC-KO and Pkd1F/RC-Mettl3-DKO mouse kidneys. Methods: m6A RNA IP using the Magna MeRIPâ¢ m6A Kit (EMD Mil

NIAID Data Ecosystem70

Next Generation Sequencing Facilitates Quantitative Analysis of mRNA lifetime of Wild Type and Mettl3-/- mice

m6A甲基化调控

树突状细胞RNA稳定性

Considering m6A modification in mRNA was reported to be intensively correlated with RNA decay, for example, T cells and neurone cells. We wondered whether deleting Mettl3, the main catalzing enzyme, a

NIAID Data Ecosystem40

Depletion of m6A methylation by conditional Mettl3 knockout in Ascl1-induced neurons

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