REGLIV

Herein, a new database, Molecular Regulation Data of Living System Facilitating Multiomics Study (REGLIV) is introduced to describe various types of molecular regulation tested by the living systems. (1) A total of 2996 regulations describe the changes in 1109 metabolites triggered by alterations in 284 genes or proteins, and (2) 1179 regulations describe the variations in 926 proteins induced by 125 endogenous metabolites. Overall, REGLIV is unique in (a) providing the molecular regulation of a clearly defined regulatory direction other than simple correlation, (b) focusing on molecular regulations that are validated in a living system not simply in an in vitro test, and (c) describing the disease/tissue/species specific property underlying each regulation.本文介绍了一款新型数据库——助力多组学研究的活体系统分子调控数据集（REGLIV），该数据库用于描述经活体系统验证的各类分子调控事件。（1）共计2996条调控记录刻画了284个基因或蛋白质的改变所引发的1109种代谢物的丰度变化；（2）1179条调控记录描述了125种内源性代谢物诱导的926种蛋白质的丰度变异。总体而言，REGLIV的独特性体现在三方面：（a）其所提供的分子调控具有明确的调控方向，而非仅为简单的关联关系；（b）聚焦于经活体系统验证的分子调控，而非仅基于体外实验得到的结果；（c）阐明了每条调控背后所蕴含的疾病、组织及物种特异性属性。

搜集汇总

背景与挑战

背景概述

REGLIV是一个专注于生命系统中分子调控的数据库，收录了数千条关于基因、蛋白质与代谢物之间调控关系的实验验证数据。它强调调控方向明确、基于活体系统验证，并记录疾病/组织/物种特异性信息。