Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snRNA-seq]

To explore the mechanistic basis of the different phases of pre- and postnatal muscle development and the contraction-dependent control of muscle gene expression , we generated a multi-omics single nucleus RNAseq (snRNA-seq) and single nucleus ATAC-seq (snATAC-seq) atlas of normal muscle and paralyzed muscle from mice lacking Cacna1s. Matthieu Dos Santos为阐明产前与产后肌肉发育不同阶段的机制基础，以及收缩依赖的肌肉基因表达调控机制，我们构建了敲除Cacna1s基因的小鼠的正常肌肉与瘫痪肌肉的多组学单细胞核RNA测序（single nucleus RNA-seq, snRNA-seq）与单细胞核转座酶可及性染色质测序（single nucleus ATAC-seq, snATAC-seq）图谱。作者：马蒂厄·多斯·桑托斯（Matthieu Dos Santos）