The essential biological properties of proteins—folding, biochemical activities, and the capacity to adapt—arise from the global pattern of interactions between amino acid residues. The statistical co
Parameters used for computation of the strength and connectivity of the FliG networks. Parameter definitions are as in Table 2.FliG Coevolution Matrix.
Communication between distant sites often defines the biological role of a protein: amino acid long-range interactions are as important in binding specificity, allosteric regulation and conformational
Amino acids are important in the structural and functional stability of proteins. We analyzed the fitness of E. coli based on the predicted coevolving amino acids essential for the function of protein
