Modulation of single-channel parameters of native If (control) by KCR1 overexpression (KCR1-infected) and knock-down of endogenous KCR1 (KCR1siRNA-infected) in adult and neonatal cardiomyocytes. Holdi
The midpoints of inactivation (V1/2) and slope factors (k) were obtained from a single or double Boltzmann fit. Values are means ± S.E.; n, number of experiments; -, not applicable. For comparison, th
Here, refers to the extracellular domain, refers to the membrane domain, and refers to the intracellular domain (see Fig 1). Note that the intracellular diffusion coefficients for Na+, K+ and are set
