Expression proteomic profiling of Niraparib and Olaparib

NIAID Data Ecosystem2026-05-02 收录

PARP抑制剂机制

癌症蛋白质组学

数据链接：

https://www.omicsdi.org/dataset/pride/PXD044333 数据链接链接失效反馈

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资源简介：

Explore protein abundance changes in several cancer cell lines upon treatment with Niraparib or Olaparib

创建时间：

2025-05-06

PARP15 catalytic domain in complex with OUL218

PARP抑制剂机制

药物靶点复合物

PARP15 catalytic domain in complex with OUL218 Descriptor: 4-(1,3-thiazol-5-ylmethoxy)benzamide, DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15 Authors: Maksimainen, M.M, Murthy, S, Le

Protein Data Bank Japan2024-01-31 更新80

Primary Myeloma Proteomics using Micro IST method

癌症蛋白质组学

多发性骨髓瘤靶点发现

The myeloma cell surface proteome (â€œsurfaceomeâ€�) not only determines tumor interaction with the microenvironment but serves as an emerging arena for therapeutic development. Here, we use glycoprot

NIAID Data Ecosystem40

PARP inhibition down-regulates constitutive Tnfα transcription.

基因表达调控

PARP抑制剂机制

(A) Real time qRT-PCR analysis of mRNA accumulation for Tnfα. Histogram indicates mRNA level of cells treated with PJ34 for 1 h (black), relative to untreated cells (grey, value ~1). Values were norma

Figshare2016-02-23 更新20

Early urine proteome changes in an implanted bone cancer rat model

癌症蛋白质组学

骨癌动物模型

Early urine proteome changes in an implanted bone cancer rat model

integrated proteome resources40

PARG inhibitor sensitivity correlates with accumulation of single strand DNA gaps in preclinical models of ovarian cancer. PARG inhibitor sensitivity correlates with accumulation of single strand DNA gaps in preclinical models of ovarian cancer

PARP抑制剂机制

药物敏感性生物标志物

Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA repair by removal of poly (ADP-ribose) (PAR) from PARP1-parylated proteins. Loss or inhibition of PARG results in re

NIAID Data Ecosystem20

Expression proteomic profiling of Niraparib and Olaparib

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