Dyhidroartemisinin alleviates restenosis after balloon angioplasty via circHSPA4 mediated SMC dedifferentiation. Rattus sp.

Restenosis after balloon angioplasty due to plasticity of vascular smooth muscle cells. In view of this, we established a rat model of carotid artery balloon injury and then use DHA as an intervention factor. Base of this, we sequenced the different expressions of circRNA profile. We screened 8 circRNAs via venn analysis. In vitro model of smooth muscle cell phenotypic modulation induced by PDGFBB, we verified CircHSPA4 serves as sponge for miR-19a-5p to induces smooth muscle cells dedifferentiation and proliferation. Previous research have shown that DHA can inhibit restenosis, we are the first to find a novel CircHSPA4 involved in this process. Our result provide a basis for DHA or miR-19a-5p as a coating drug on balloon catheter to improve the success rate of angioplasty.