BTX-A delivery to the gastric muscularis achieves effective weight control and metabolic improvement

In this study, we developed a novel layer-specific gastric paralysis microneedles (LGP-MN) based on the method of gastric neuromodulation therapy, which can to solve the problems in traditional injection therapy and achieve precise, uniform and safe delivery of therapeutic drugs BTX-A intoat different designated layerevels of the gastric wall.