Homo sapiens Transcriptome or Gene expression

Extranodal NK/T-cell lymphomas (NKTCLs) and gamma-delta peripheral T-cell lymphomas (?d-PTCLs) are rare lymphomas with poor prognosis. There is little insight into the role of oncogenic mutations in these allied cancers. Here, we analyzed the genome-wide mutation profile on 17 NKTCL cases and relevant NK/T-Cell lines by performing RNA sequencing and observed frequent oncogenic mutations in STAT3, STAT5B and other JAK-STAT pathway genes.