Human Protein Atlas - Brain

This section provides comprehensive spatial profiling of the Brain, including overview of protein expression in the mammalian brain based on integration of data from human, pig and mouse. Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is available in this brain-centric sub atlas of the Human Protein Atlas. The data presented are for human genes and their one-to-one orthologues in pig and mouse. Gene summary pages provide the hierarchical expression landscape form 13 main regions of the brain to individual nuclei and subfields for every protein coding gene. For selected proteins, high content images are available to explore the cellular and subcellular protein distribution. In addition, the Brain section contains lists of genes with elevated expression in one or a group of regions to help the user identify unique protein expression profiles linked to physiology and function.
More information about the specific content and the generation and analysis of the data in this section can be found on the Methods Summary.
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Expression levels for all human proteins in regions and subregions of the human brain
Expression levels for all proteins with human orthologs in regions and subregions of the pig and mouse brain
Brain enriched genes with higher expression in any of the regions of the brain compared to peripheral organs
Regional enriched genes with higher expression in a single or few regions of the brain
Cell-type and cell-compartment distribution of selected proteins in the human and mouse brain
Differences in gene expression between mammalian species

本节提供了对大脑的全面空间描述，包括基于整合人、猪和鼠脑数据对哺乳动物脑中蛋白质表达情况的概述。该子图谱以大脑为中心，提供了转录组学数据与基于亲和力的蛋白质原位定位相结合，直至单细胞细节的数据。展示的数据涉及人类基因及其在猪和鼠中一对一的直系同源基因。基因摘要页面提供了从大脑13个主要区域至每个蛋白质编码基因的单一核和亚域的层级表达景观。对于选定的蛋白质，提供了高内涵图像，以探索细胞和亚细胞蛋白质分布。此外，大脑部分还包含在特定区域或一组区域中表达升高的基因列表，以帮助用户识别与生理和功能相关的独特蛋白质表达模式。有关本节特定内容以及数据的生成和分析方法的更多信息，请参阅方法摘要。了解以下内容：
- 人类大脑各区域和亚区域中所有蛋白质的表达水平
- 猪和鼠大脑中所有具有人类直系同源基因的蛋白质的表达水平
- 在大脑区域中相对于外周器官表达更高的富集基因
- 在大脑单个或少数区域中表达更高的区域富集基因
- 人类和鼠脑中选定蛋白质的细胞类型和细胞区室分布
- 哺乳动物物种之间基因表达的差异