Human Protein Atlas - Brain

This section provides comprehensive spatial profiling of the Brain, including overview of protein expression in the mammalian brain based on integration of data from human, pig and mouse. Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is available in this brain-centric sub atlas of the Human Protein Atlas. The data presented are for human genes and their one-to-one orthologues in pig and mouse. Gene summary pages provide the hierarchical expression landscape form 13 main regions of the brain to individual nuclei and subfields for every protein coding gene. For selected proteins, high content images are available to explore the cellular and subcellular protein distribution. In addition, the Brain section contains lists of genes with elevated expression in one or a group of regions to help the user identify unique protein expression profiles linked to physiology and function. More information about the specific content and the generation and analysis of the data in this section can be found on the Methods Summary.Learn about:Expression levels for all human proteins in regions and subregions of the human brainExpression levels for all proteins with human orthologs in regions and subregions of the pig and mouse brainBrain enriched genes with higher expression in any of the regions of the brain compared to peripheral organsRegional enriched genes with higher expression in a single or few regions of the brainCell-type and cell-compartment distribution of selected proteins in the human and mouse brainDifferences in gene expression between mammalian species

本节提供了大脑的全面空间分析，包括基于人类、猪和鼠的数据整合，对哺乳动物大脑中蛋白质表达情况的概述。本子图谱以人类蛋白质图谱为中心，集成了转录组学数据与基于亲和力的蛋白质原位定位，直至单细胞水平。所展示的数据涵盖了人类基因及其在猪和鼠中的一对一同源基因。基因概要页面提供了从大脑的13个主要区域到每个蛋白质编码基因的个体核和亚领域的层次表达景观。对于选定的蛋白质，还提供了高内涵图像，以便探索细胞和亚细胞蛋白质分布。此外，大脑部分还包含了在单个或一组区域中表达升高的基因列表，以帮助用户识别与生理和功能相关的独特蛋白质表达谱。关于本节特定内容以及数据的生成和分析的更多信息，可在方法概要中找到。了解以下内容：人类大脑区域和亚区域中所有人类蛋白质的表达水平；猪和鼠大脑区域和亚区域中所有具有人类同源基因的蛋白质的表达水平；在大脑区域中相对于外围器官表达更高的脑富集基因；在单个或少数大脑区域中表达更高的区域富集基因；人类和鼠大脑中选定蛋白质的细胞型和细胞器分布；哺乳动物物种之间基因表达的差异。