To understand how age rewires the chromatin accessibility landscape, we molecularly profiled 23 purified cell types from 11 tissues and organs by assessing the cumulative signature of 15-25 young and

NIAID Data Ecosystem50

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity

子宫内膜癌

增强子调控

FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and uterine development. Ho

NIAID Data Ecosystem30

PHF13 Activates Enhancers to Promote TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq]. PHF13 Activates Enhancers to Promote TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq]

上皮-间质转化机制

增强子调控

We investigated the role of PHF13 in TGFβ-induced Epithelial-to-Mesenchymal Transition and found PHF13 is essential for TGFβ-promoted broadest H3K4me3 domains and super-enhancers activation. Overall d

NIAID Data Ecosystem70

Super-enhancer RNA seRNAHP promotes liver regeneration via upregulation of phosphoglycerate dehydrogenase and serine biosynthesis

肝脏再生机制

增强子调控

A 70% partial hepatectomy (PHx) was performed on male super-enhancer Nacc1-SE (located near the Nacc1 gene) knockout mice to evaluate the contribution of Nacc1-SE to liver regeneration. In vitro, prim

NIAID Data Ecosystem40

Supplementary Table S1 from BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

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