We successfully develop a two-in-one approach to generate non-viral genome specific targeted CAR T cells through CRISPR/Cas9. In the adoptive therapy for relapsed/refractory aggressive B-cell non-Hodg

NIAID Data Ecosystem60

Additional file 10 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model

基因编辑脱靶效应

转录组分析

Additional file 10: Table S8. Transcriptome profiles of HEK293T transfected of RfxCas13d, NeuN and crRNA (Linked to Response Fig. 8 of first revision).

Figshare2024-02-07 更新40

High-throughput sequencing of Epidermolysis Bullosa- and Epidermolytic Ichthyosis-associated genomic regions in primary keratinocytes (Ion Torrent amplicon panel)

遗传性皮肤病

基因编辑脱靶效应

We developed a comprehensive AmpliSeq panel for NGS analysis of EB and EI-asociated genomic loci. These included mutation hotspots and predicted off-target sites for gene editing agents. Some of the

NIAID Data Ecosystem60

Extru-seq

基因编辑脱靶效应

益生菌基因组安全评估

Extru-seq data in prediction of Genome-wide off-target effect

NIAID Data Ecosystem60