M6A immunoprecipitation from 15min BrU labeled and fragmented nascent RNA. HEK293T cells were incubated with 2 mM bromouridine for 15 min labeling time (pulse). Whole-cell total RNA was extracted with
This study aims to investigate the enzymatic properties and evolutionary conservation of METTL4, a novel internal m6A(m) methyltransferase involved in U2 snRNA modification during spliceosome assembly
N6-methyladenosine (m6A) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. m6A is thought to mediate its effects through a co
