3-Bromopyruvate (3BP) is a potential anticancer agent viewed as a glycolytic inhibitor that preferentially kills cancer cells through inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), re

NIAID Data Ecosystem40

VDAC2 ligands selectively and potently block BAK-mediated apoptosis to allow long-term clonogenic cell survival

细胞凋亡抑制

药物靶点鉴定

This study aimed to characterise the protein that a novel compound binds to, thus promoting its ability to inhibit BAK apoptotic activity.

NIAID Data Ecosystem20

Enhancing Comprehensive Analysis of Newly Synthesized Proteins Based on Cleavable Bioorthogonal Tagging

化学蛋白质组学

新合成蛋白质分析

Protein synthesis and degradation responding to environmental cues is critical for understanding the mechanisms involved. Chemical proteomics introducing bioorthogonal tagging into proteins and isolat

NIAID Data Ecosystem40

Chemoproteomic Identification of Blue-Light-Damaged Proteins

蛋白质光损伤

化学蛋白质组学

Visible light, particularly in the blue region of the spectrum, can cause cell dysfunction through the generation of singlet oxygen, contributing to cellular aging and age-related pathologies. Althoug

NIAID Data Ecosystem30

TMT-ABPP profiling of SP3CHO in native 293T proteome

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