Bacterial community of apical periodontitis

Apical periodontitis is essentially an inflammatory disease of microbial etiology primarily caused by infection of the pulp and root canal system. Variation of the bacterial communities caused by apical periodontitis, as well as their changes responding to dental therapy, are of utmost importance to understand the pathogensis of the apical periodontics and establishing effective antimicrobial therapeutic strategies. This study used deep sequencing to uncover the composition and diversity of microbiota associated to the pulp and the root canal system to identify the relevant bacteria highly involved in apical periodontitis, with the consideration of root apex samples from the infected teeth (with/without root canal treatment), healthy teeth as well as the healthy oral.