To analyze the effect of type I IFN on global gene expression in differentiating monocytes, we employed microarray-based gene expression profiling. The MACS-purified mouse BM monocytes were cultured i
A number of IFN-induced proteins are believed to be responsible for the antiviral state induced by IFNs. Our microarray analysis of IFN-regulated genes in MEFs from wild-type mice identified 124 probe
The goal is to assess whether interferon-inducible RNA regulates type I IFN through cytosolic RNA sensor MDA5. Huh7 cells were treated with or without IFN beta. Anti-MDA5 immunoprecipitation was condu
GAF is transcriptionally inactive in epithelial cells but enhances expression of ISGF3 target genes, thus functioning as a dose-sensitive amplifier of the IFN-𝛽 response. Sequencing data from MLE-12
