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Phosphine-Mediated Stereoselective Reductive Cyclopropanation of α-Substituted Allenoates with Aromatic Aldehydes

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NIAID Data Ecosystem2026-03-06 收录
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A novel phosphine-mediated reductive cyclopropanation between α-substituted allenoates 2 and aldehydes 1 is described. It represents a new member of the allene-based annulations, which provides facile and efficient access to highly functionalized cyclopropanes 3 from simple and readily available starting materials. It also unveils an unprecedented reactivity pattern of allenoates with aldehydes.

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2010-02-05
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