Impaired gene expression in ATRX-depleted cells following interferon signaling

We investigated the role of the chromatin remodeling protein ATRX on ISG expression upon stimulation with IFN-ß utilizing doxycycline-inducible ATRX knockdown cells. Overall design: Examination of differential gene expression by RNA-seq in human foreskin fibroblasts (doxycycline-inducible ATRX knockdown cells and control cells) treated with IFN-ß.