Huntington's disease (HD) is associated with dysfunction of the blood-brain barrier, including brain microvasscular endothelial cells (BMECs). We report changes in gene expression of induced pluripote
To gain an overview of the cellular impact of Guanabenz analogues, we analyzed the gene expression changes in PC12 cells expressing GFP-mHtt-74Q utilizing Affimatrix rat genome microarrays. Following
Selected autophagy markers were analyzed by qRT-PCR in hypothalamic tissue from mice injected with rAAV5-htt853-79Q or rAAV5-htt853-18Q and uninjected controls, 8 weeks post injection (n = 7/group). T
Long-term implantation of human NSCs in Huntington’s disease (HD) mice ameliorates behavioral deficits and reduces mutant Huntingtin accumulation. The human NSCs survive and differentiate into diverse
