A Community Screening Tool for Neuropsychiatric Symptoms in the Elderly: Integrating Cortisol, Microbiome, and Social Factors with Machine Learning

In this study, we aimed to develop and validate a community-based screening tool for NPS in the elderly using interpretable machine learning algorithms. We also compared the performance of these models from the perspective of oral microbiome data by 16S rRNA. Furthermore, we analyzed the model features to explore the potential metabolic pathways underlying their association with NPS, thus providing deeper insights into the biological relevance of biomarkers