Enantioselective 1,4-Addition of Unmodified Ketone Catalyzed by a Bimetallic Zn−Zn-Linked−BINOL Complex
收藏NIAID Data Ecosystem2026-03-06 收录
数据链接：
官方服务：
资源简介：
1,4-Addition (Michael addition) of 2-hydroxy-2‘-methoxyacetophenone (2) to various α,β-unsaturated ketones was efficiently promoted by a bimetallic Zn−Zn-linked−BINOL complex 3 with good yield (up to 90%) and excellent enantiomeric excess (up to 99% ee). The resulting 2-hydroxy-1,5-diketones were successfully converted to synthetically more versatile esters and amides.
创建时间：
2016-08-20
