Transition from Compensated Hypertrophy to Systolic Heart Failure in the Spontaneously Hypertensive Rat

Besides these individual transcripts, gene set enrichment analysis (GSEA) identified multiple enriched pathways with HF, most prominent of the altered signaling pathways involved TGF-ß and insulin signaling. GESA analysis additionally identified altered gene sets involving inflammation, oxidative stress, cell degradation and cell death, among others (all p<0.01). In contrast to diastolic HF where few transcripts are reported to be altered, our data indicate multiple genes and pathways involved in a variety of biological processes characterize the onset of systolic HF, consistent with many functional and structural changes present in the failing hypertensive heart.除上述单个转录本外，基因集富集分析（gene set enrichment analysis, GSEA）识别出多条与心力衰竭（heart failure, HF）相关的富集通路，其中发生改变的信号通路以转化生长因子β（TGF-β）与胰岛素信号通路最为突出。GSEA分析还识别出涉及炎症、氧化应激、细胞降解及细胞死亡等过程的异常基因集（所有P值均<0.01）。与鲜有转录本被报道发生改变的舒张性心力衰竭不同，本研究数据显示，多种生物学过程相关的大量基因及通路共同构成收缩性心力衰竭的发病特征，这与衰竭高血压性心脏中存在的诸多功能与结构改变高度一致。