Transcriptional dysregulation in Huntington’s disease (HD) is an early event that affects the expression of genes involved in survival and neuronal functions throughout the progression of the patholog
Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease
Cortex was isolated from 6-month-old Msh3+/- and Msh3-/- mice crossed with the Q140 knock-in (KI) HD mice and their respective controls. Transcriptomic analysis (RNASeq) was performed on 6 genotypes: