BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion

NIAID Data Ecosystem2026-05-02 收录

细胞衰老机制

代谢疾病分子通路

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https://data.mendeley.com/datasets/x2mr988fvk 数据链接链接失效反馈

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资源简介：

Source files and raw imaging data for Figures 1-6 and Supplementary Figures S1, S2, S4-S6.

创建时间：

2024-06-24

Expression data from IMR90 cells expressing either E7-ca-STAT5A-shNTC vs E7-ca-STAT5a-shSOCS1 at 7 days post infection

细胞衰老机制

STAT信号通路

SOCS1 plays a role in cellular senescence. Knocking down SOCS1 in senescence induced by the STAT5 oncogene results in senescence bypass by preventing p53 activation IMR90 cells were infected with retr

NIAID Data Ecosystem80

Age-associated dysregulation of peroxisomal matrix protein importing impairs intestinal stem cell differentiation and gut functions

细胞衰老机制

肠道干细胞

Age-associated dysregulation of peroxisomal matrix protein importing impairs intestinal stem cell differentiation and gut functions

integrated proteome resources50

Human Keratinocytes That Express hTERT and Also Bypass a p16(INK4a)-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

角质形成细胞永生化

细胞衰老机制

Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence. Progressive telomere shortening appears to trigger senescence in norm

PubMed Central40

Effect of overexpression of aging-associated transcription factors on epithelial cells.

细胞衰老机制

转录因子功能

RNA-seq profiling of whole, intact uteri at embryonic day 3.5 (E3.5) from young and aged virgin wild-type C57BL/6 miceâeach mated with vasectomized wild-type malesâidentified the transcription fac

NIAID Data Ecosystem50

ATF3 drives senescence by reconstructing accessible chromatin profiles

细胞衰老机制

染色质可及性分析

We depicted the landscapes of both chromatin accessibility and gene expression to reveal gene regulatory networks in human umbilical vein endothelial cell (HUVEC) senescence and found that chromatin a

NIAID Data Ecosystem40

BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion

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