Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-38
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Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-38 Descriptor: (2~{S})-~{N}-[5-(4-azanyl-8-fluoranyl-quinazolin-7-yl)-2-fluoranyl-phenyl]sulfonylpyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, MAGNESIUM ION, ... Authors: Luo, Z, Zhou, H. Deposit date: 2023-09-03 Release date: 2024-09-04 Last modified: 2025-09-17 Method: X-RAY DIFFRACTION (1.824 Å) Cite: Development of potent inhibitors targeting bacterial prolyl-tRNA synthetase through fluorine scanning-directed activity tuning. Eur.J.Med.Chem., 291, 2025
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2023-09-03
