Additional file 11: of Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

Adaptive model analysis and ROC curve in gene expression changes of the 41 transcripts across 28 subjects (14 subjects × 2 trials) in the MDS. Red lines: individual limits as determined by the adaptive model for a specificity of 99%; blue line: actual test results. The first 1–14 graphs: subjects participated in the rHuEpo trial and following 15–28 graphs: the same subjects participated in the placebo trial. X-axis: 13 time points and y-axis: log2 gene expression. (ZIP 1076 kb)