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Duplications disrupt chromatin architecture and rewire GPR101-enhancer communication in X-linked acrogigantism

NIAID Data Ecosystem2026-05-02 收录

遗传疾病机制

染色质构象

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE193114 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-10-08

染色质构象

DNA甲基化与基因表达调控

We engineered a H1 knockout mutant in Arabidopsis thaliana which shows pleiotropic phenotypes. Using High-throughput Chromosome Conformation Capture (Hi-C), we found that H1 depletion dampens inter- a

NIAID Data Ecosystem80

Chromatin structure dynamics of hoxa13a, hoxa13b and hoxd13a loci during zebrafish development.

染色质构象

发育基因调控

We designed 4C-Seq experiments for hoxa13a, hoxa13b and hoxd13a promoters in three developmental stages in zebrafish embryos: 24, 48 and 60 hpf. 4C-seq samples for three different hox13 genes promoter

NIAID Data Ecosystem60

ChIA-PET from GM19240 (ENCSR782XOF)

染色质构象

遗传学数据

H3K27ac ChIA-PET in GM19240 For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Use

NIAID Data Ecosystem30

NG Capture-C analysis of GADD45a-bound adipogenic super-enhancers

染色质构象

脂肪生成

ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We previously found that ING1b is essential to target GADD45a-mediated active DNA-demethylat

NIAID Data Ecosystem70

EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.[DND41_4C]

T-ALL耐药机制

染色质构象

Purpose: To investigate the mechanisms of 3D genome organization in drug-resistant T-ALL Methods: We used multiple epigenomics, chromatin conformation, and transcriptomic assays to study the mechanism

NIAID Data Ecosystem50

Duplications disrupt chromatin architecture and rewire GPR101-enhancer communication in X-linked acrogigantism

资源简介：

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