Details of Vellore-based studies used as primary data sources for the estimation of cryptosporidial disease burden in Indian children.

* This was a multi-centric study. Data on diarrhea-related hospitalizations among the 1500 children recruited from rural and urban areas of Vellore district only was available and was used for this analysis.†Estimated indirectly by applying the 2.7% Cryptosporidium detection rate (using microscopy) in hospitalized children [16] to the all-cause diarrhea hospitalization rate.ΔRate obtained by multiplying the rate of hospitalization from Cryptosporidium-associated diarrhea using microscopy with a factor of 3 (to adjust for the increased sensitivity of PCR vis-à-vis microscopy [27]).