Age-related tissue alterations have been associated with a decline in stem cell number and function. Increased cell-to-cell variability in transcription or epigenetic marks has been proposed to be a m

干细胞与再生医学数据中心2022-02-20 更新100

Epigenetic stress responses induce muscle stem cell aging by Hoxa9 developmental signals [RNA-seq]

表观遗传学

干细胞生物学

Background and Aims: Analysis of aging-induced impairments in satellite cells (SCs) â the stem cells of skeletal muscle that are required for its regeneration. Hox genes are known to control stem ce

干细胞与再生医学数据中心2022-02-20 更新80

NANOS2-binding regulates mRNA half-life and key spermatogonial stem cell self-renewal pathways

基因表达调控

干细胞生物学

We have identified NANOS2 bound targets transcriptome wide by employing CRAC and RNA-seq in mouse SSCs. We have determined the average mRNA half-life in SSCs by SLAM-seq. By comparing CRAC and SLAM-se

干细胞与再生医学数据中心2022-02-20 更新100

RNAseq of Polycomb KD ISCs

干细胞生物学

基因表达调控

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains large

干细胞与再生医学数据中心2022-02-20 更新100

Runx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells

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