首页/数据集/The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity

The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity

ChEBI2013-03-19 更新2026-07-21 收录

耐药性前列腺癌

激素受体信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-38851 数据链接链接失效反馈

官方服务：

资源简介：

The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity

应用场景：

创建时间：

2013-03-19

前列腺癌分子机制

激素受体信号通路

We found that ERbeta activated by ligand eithe E2 or LY3201 repressed AR activity and affected downstream genes regulated by AR Overall design: To investigate the mechanisms of action of ERÃ and its

NIAID Data Ecosystem70

A somatically acquired enhancer of the androgen receptor is a noncoding driver in advanced prostate cancer. A somatically acquired enhancer of the androgen receptor is a noncoding driver in advanced prostate cancer

耐药性前列腺癌

非编码增强子

Increased androgen receptor (AR) activity drives therapeutic resistance in advanced prostate cancer. The most common resistance mechanism is amplification of this locus presumably targeting the AR gen

NIAID Data Ecosystem40

A genome-wide CRISPR activation screen identifies PRRX2 as a regulator of enzalutamide resistance in prostate cancer [ATAC-seq]. A genome-wide CRISPR activation screen identifies PRRX2 as a regulator of enzalutamide resistance in prostate cancer [ATAC-seq]

耐药性前列腺癌

CRISPRi功能基因组学

We report that PRRX2 mediates enzalutamide resistance by activating the anti-apoptotic BCL2 and theE2F/RB1 cell cycle pathways. Overall design: We used LNCaP cells to over-express the transcription fa

NIAID Data Ecosystem20

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance. GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

耐药性前列腺癌

雄激素受体信号

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here we show that the magnitude of AR signaling output, independent of AR

NIAID Data Ecosystem70

Time-course effect of estradiol and ERa17p on Early Gene expression in SKBR3 cells

乳腺细胞分子机制

激素受体信号通路

Time-course effect of estradiol and ERa17p on Early Gene expression in SKBR3 cells

ChEBI2012-07-30 更新20