Enantioselective Vinylogous Michael–Michael Cascade Reactions of 3‑Alkylidene Oxindoles and Nitroolefin Enoates
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A novel bifunctional squaramide catalyzed vinylogous Michael–Michael cascade reaction of 3-alkylidene oxindoles with nitroolefin enoates was developed. This convenient, one-pot cascade reaction serves as a powerful tool for the enantioselective construction of potential bioactive chiral chromans, which have three continuous tertiary stereocenters, in moderate to good yields (up to 85%) with excellent stereoselectivities (up to >19:1 dr and >99% ee).
创建时间：
2017-07-03
