PPI datasets used in this study contain 1622 and 3006 proteins for yeast and human respectively [23]. In yeast, all of these proteins can be found in the abundance datasets [3, 16], while in human onl
The Mediator complex regulates transcription by connecting enhancers to promoters. High Mediator binding density is one defining feature of so-called super enhancers, which regulate cell-identity gene
This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.
All P<0.0001. aAverage number of interactions observed between essential proteins for 1000 simulations in which essential proteins were selected randomly from all proteins occurring in a network. In e
