SCDC: Deconvolution of Bulk Gene Expression by Single-Cell RNA Sequencing Data

This paper describes SCDC, a deconvolution method for bulk RNA-seq that leverages cell-type specific gene expression profiles from multiple scRNA-seq reference datasets. SCDC adopts an ENSEMBLE method to integrate deconvolution results from different scRNA-seq datasets produced in different conditions, implicitly addressing the batch-effect confounding.本文介绍了SCDC——一种面向批量RNA测序（bulk RNA-seq）的反卷积方法，该方法可利用来自多个单细胞RNA测序（scRNA-seq）参考数据集的细胞类型特异性基因表达谱。SCDC采用集成（ENSEMBLE）方法，对不同实验条件下产生的各类scRNA-seq数据集的反卷积结果进行整合，从而隐式地解决了批次效应混杂问题。