Replication of conditional analysis.

*Odds ratios (OR) were calculated for the risk allele (shown in bold).In the replication dataset, SNP1 and SNP3 were genotyped, SNP2 was not genotyped and did not impute, SNP4 was imputed (info score = 0.95). We used imputed genotype probabilities in the R software, adjusting for age and sex for replication, and adjusting for age, sex and study for pooled data. Replication P values are one sided [28] given the directionality of the hypothesis; P values for pooled NGRC and replication are two sided.