Sensitivity analysis: Study deviated from HWE were excluded in Asians under all models and for overall studies in recessive model.

M, Statistical model. R, random-effects model; F, fixed-effects model. PZ, P value for Z test; PH, P value for heterogeneity. SA-A: Sensitivity analysis (Study deviated from HWE were exclude).in Asians. SA-O: Sensitivity analysis (Study deviated from HWE were exclude).in overall studies. *:the association is sill significant after Bonferronic correction for multiple testing.