Iridium-Catalyzed Direct Hydroarylation of Glycals via C–H Activation: Ligand-Controlled Stereoselective Synthesis of α- and β‑<i>C</i>‑Glycosyl Arenes

Diastereoselective direct hydroarylation of glycals with aromatic compounds was realized by use of an iridium/binap catalyst, giving the corresponding C-glycosyl compounds in high yields. The use of binap with the different absolute configuration enabled the stereoselective synthesis of α- or β-C-glycosyl arenes irrespective of the chirality of the glycals. The method showing the high functional group tolerance provides an atom-economical access to C-glycosyl arenes by way of C–H bond activation