Power for 500–2000 trios and 500K markers, using mating type ratio equation R4, under an additive genetic model.

Estimated power levels to detect the DSL using 500–2000 trios, assuming a 10% disease prevalence and additive mode of inheritance. The significance level is set to 5%. For the weighted Bonferroni method (Weighted), the partitioning parameters are K = 7 and r = 2. MAF denotes minor allele frequency. The power reflects the proportion of times the p-value of the DSL (Independence scenario and LD scenario (DSL only)) or a SNP in LD with the DSL (LD scenario (DSL+)) met the weighted Bonferroni (Weighted) or standard Bonferroni corrected (Standard) significance level. The standard Bonferroni correction adjusts for 500 K comparisons.