Although the lineage-determining ability of transcription factors is often modulated according to cellular context, the mechanisms by which such switching occurs are not well known. Using a transcript
Expression analysis of ADRN cell line SH-SY5Y with transient- or permanent doxycycline-inducible NOTCH3-IC expression was used to study reversibility of transcriptional reprogramming. Overall design:
Rice-pathogenic Xanthomonas oryzae bacteria cause severe harvest loss and challenge a stable food supply. The pathogen virulence relies strongly on bacterial TALE (transcription activator-like effecto
Saccharomyces cerevisiae mutants have been used since the early 1980s as a tool to clone genes from other organisms by functional complementation. This approach has been extremely successful in clonin
