While there is extensive evidence for genetic variation as a basis for treatment resistance, other sources of variation result from cellular plasticity. Using multiple myeloma as an example of an incu
Gene regulation through promoter engineering is a cornerstone of synthetic biology, enabling precise control over transcriptional networks. However, experimental approaches remain labor-intensive. Whi
Acute erythroid leukemia (AEL) most commonly involves transformation of both the myeloid and erythroid lineages. However, the mutations that cause AEL and the nature of the transformed cell that susta
