Dopaminergic and serotonergic ligands miscue regeneration.
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Results from pharmacological screen investigating the impact of different agents that modify neurotransmission on planarian regenerative polarity. Each ligand within the different classes was tested up to the indicated concentration after first performing toxicity assays to identify the concentration range over which worm viability was unaffected. In each test, drug exposure was for one day using cohorts of n≥30 worms for n = 3 trials. A lack of effect in regenerative polarity is indicated by ‘-’, whereas polarity defects (phenotype and penetrance) are described. Drugs were sourced as follows:1Sigma Aldrich,2Tocris Bioscience,3Invitrogen.
创建时间：
2015-12-02
