Modulation of the microhomology-mediated end joining pathway

NIAID Data Ecosystem2026-05-01 收录

基因编辑机制

DNA损伤修复调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA953777 数据链接链接失效反馈

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资源简介：

Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks

创建时间：

2023-04-09

Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response. Walser et al

泛素磷酸化修饰

DNA损伤修复调控

Modification of ubiquitin by phosphorylation is a new and largely unexplored concept in the field. Here we found that ubiquitin phosphorylation at Thr12 (pUbT12) represents a novel histone mark, H2AK1

NIAID Data Ecosystem10

SMARCA4-loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer

卵巢癌分子机制

DNA损伤修复调控

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive cancer mainly affecting young women. It is driven by inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chr

NIAID Data Ecosystem00

Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in an intermediate state

CRISPR-Cas结构生物学

基因编辑机制

Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in an intermediate state Descriptor: CRISPR-associated endonuclease Cas9, Non-target DNA strand, Target DNA strand, ... Authors: Omura, S.

Protein Data Bank Japan2026-04-29 更新00

Table2_PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP.XLSX

DNA损伤修复调控

蛋白质翻译后修饰

Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)—interacting p

NIAID Data Ecosystem10

SMARCA4-loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer

卵巢癌分子机制

DNA损伤修复调控

NIAID Data Ecosystem00