An extremely drug resistant mutant of HIV-1 protease (PR) bearing 20 mutations (PR20) has been studied with two potent antiviral investigational inhibitors. GRL-5010A and GRL-4410A were designed to in

NIAID Data Ecosystem20

Supplementary data for "Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core"

整合素抑制剂发现

药物化学筛选

Supplementary dataset related to the paper: "Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core Integrins αvβ5 and αvβ3 are closely related, proangio

DataCite Commons2021-02-18 更新20

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

抗菌药物发现

抑制剂优化

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Descript

Protein Data Bank Japan2024-02-28 更新30

DataSheet5_Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening.ZIP

抑制剂设计

抑制剂优化

Primary hyperoxaluria type I (PH1) is caused by AGXT gene mutations that decrease the functional activity of alanine:glyoxylate aminotransferase. A build-up of the enzyme’s substrate, glyoxylate, resu

NIAID Data Ecosystem20

Data for: Optimization of Novel Reversible Bruton's Tyrosine Kinase Inhibitors Identified using Tethering-Fragment-Based Screens

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