Mesoscale DNA Feature in Antibody-Coding Sequence Facilitates Somatic Hypermutation

Somatic hypermutation (SHM), initiated by activation-induced cytidine deaminase(AlD), generates a pool of mutations in antibody-coding sequence to allow affinitymaturation upon pathogen invasion. Why these mutations are intrinsically focusedon the three nonconsecutive complementarity-determining-regions (CDRs) remainsenigmatic.